Neurology Medical News about primary progressive multiple sclerosis;cognitive dysfunction

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Cognitive dysfunction in primary progressive multiple sclerosis: A neuropsychological and MRI study
Multiple Sclerosis, 06/29/09

Ukkonen M et al. – A study of cognitive dysfunction in multiple sclerosis (MS) focuses on cognitive performance in primary progressive MS (PPMS)and reports impairment in several cognitive domains.

Methods

Study of the pattern of cognitive performance in PPMS
Extensive battery of neuropsychological tests for 28 PPMS pts
Comparison of results to those of 20 healthy controls and 28 pts with secondary progressive MS (SPMS)
Correlation of results of neuropsychological tests in PPMS with magnetic resonance imaging findings

Results

Deficits in several cognitive domains for PPMS pts vs age-matched and education-matched controls
Cognitive impairment similar for PPMS and SPMS pts
Correlations for cognitive deficits in PPMS pts with diffuse brain lesion, T1- and T2-lesion loadl no correlations with atrophy

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