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Cognitive dysfunction in primary progressive multiple sclerosis: A neuropsychological and MRI study
Multiple Sclerosis, 06/29/09
Ukkonen M et al. – A study of cognitive dysfunction in multiple sclerosis (MS) focuses on cognitive performance in primary progressive MS (PPMS)and reports impairment in several cognitive domains.
Methods- Study of the pattern of cognitive performance in PPMS
- Extensive battery of neuropsychological tests for 28 PPMS pts
- Comparison of results to those of 20 healthy controls and 28 pts with secondary progressive MS (SPMS)
- Correlation of results of neuropsychological tests in PPMS with magnetic resonance imaging findings
- Deficits in several cognitive domains for PPMS pts vs age-matched and education-matched controls
- Cognitive impairment similar for PPMS and SPMS pts
- Correlations for cognitive deficits in PPMS pts with diffuse brain lesion, T1- and T2-lesion loadl no correlations with atrophy
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Effect of glatiramer acetate on conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome (PreCISe study): a randomised, double-blind, placebo-controlled trial : The Lancet
The Lancet - Early Online Publication, 10/08/09
Long-term effect of early treatment with interferon beta-1b after a first clinical event suggestive of multiple sclerosis: 5-year active treatment extension of the phase 3 BENEFIT trial
The Lancet Neurology, 10/16/09
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