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Cognitive dysfunction in primary progressive multiple sclerosis: A neuropsychological and MRI study
Multiple Sclerosis, 06/29/09

Ukkonen M et al. – A study of cognitive dysfunction in multiple sclerosis (MS) focuses on cognitive performance in primary progressive MS (PPMS)and reports impairment in several cognitive domains.

• Study of the pattern of cognitive performance in PPMS
• Extensive battery of neuropsychological tests for 28 PPMS pts
• Comparison of results to those of 20 healthy controls and 28 pts with secondary progressive MS (SPMS)
• Correlation of results of neuropsychological tests in PPMS with magnetic resonance imaging findings

• Deficits in several cognitive domains for PPMS pts vs age-matched and education-matched controls
• Cognitive impairment similar for PPMS and SPMS pts
• Correlations for cognitive deficits in PPMS pts with diffuse brain lesion, T1- and T2-lesion loadl no correlations with atrophy

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