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Prognostic factors of subthalamic stimulation in Parkinson’s disease: A comparative study between short- and long-term effects
Stereotactic and Functional Neurosurgery , 06/30/09

Tsaia ST et al. – Prognostic factors for subthalamic nucleus deep brain stimulation (STN-DBS) benefit differed for short- and long-term follow-ups. Good prognostic factors for long-term STN-DBS for PD pts were good cognitive function and tremor dominance. Poor prognostic factors were related to older age and non-dopaminergic-responsive axial disability.

• Study of prognostic factors for short- and long-term effects of STN-DBS
• Bilateral STN-DBS for 36 PD
• Clinical evaluations 1 mo before and 3 mo after surgery, with additional follow-up examinations for a mean of 31.3 mo

• Trend for long-term STN-DBS-induced improvements in Unified Parkinson's Disease Rating Scale (UPDRS) part II and part III measures greater in younger pts
• Preoperative levodopa responsiveness only led to consistent UPDRS part III improvement from STN-DBS at 3 mo; this predictive value did not exist in the long term
• Preoperative levodopa response of tremor and axial symptoms in motor disability predicted long-term DBS effect only
• Preoperative cognitive function positively correlated with postoperative improvement from DBS in UPDRS part III during long-term follow-up only

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