Neurology Medical News about resting brain fluctuations;key role coupling

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Key role of coupling, delay, and noise in resting brain fluctuations
Proceedings of the National Academy of Sciences of the United States of America, 06/29/09

Deco G et al. – Results specify an optimal sensitivity for conduction velocities with weak coupling between oscillators and a characteristic scale for optimal noise level, indicating presence of stochastic resonance, which allows network dynamics to respond with high sensitivity to changes in diffuse feedback activity.

Methods

Numerical simulation study of dynamics of a simplified cortical network using 38 noise-driven (Wilson–Cowan) oscillators
Use in isolation to maintain status just below oscillatory threshold
Time delay coupling based on lengths and strengths of primate corticocortical pathways
Systematic variation of conduction velocity, coupling strength, and noise level

Results

Emergence of 2 sets of 40-Hz oscillators
Sets showed synchronization anticorrelated at <0.1 Hz across sets with wide range of recent experimental observations
High sensitivity of emerging synchrony and simulated blood flow blood oxygen level-dependent (BOLD) on underlying parameter values
Optimal sensitivity at conduction velocities ~1–2 m/s, with very weak coupling between oscillators

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