Neurology Medical News about seizure frequency;sex steroids in women;partial epilepsy;antiepileptic therapy

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Seizure frequency and sex steroids in women with partial epilepsy on antiepileptic therapy
Epilepsia, 06/25/09

Murialdo G et al. – Actual changes in sex steroid levels and estradiol (E2)/ progesterone (Pg) ratios did not explain an increased seizure frequency in adult women with antiepileptic drug (AED)-treated partial epilepsy (PE), but pts with more severe disease showed more relevant changes in their sex hormone profile and impaired Pg levels during the luteal phase.

Methods

Cross-sectional observational study of relationships between sex steroids, seizure frequency, and other clinical parameters in 72 adult women with PE on AED treatments and 30 healthy controls
Determination of serum E2, Pg, sex hormone binding globulin (SHBG) levels, free E2 (fE2), and E2/Pg ratios during follicular and luteal phases
Correlation of hormonal data with seizure frequency, age, body weight, body mass index (BMI), disease onset and duration, and AED therapies

Results

Lower E2, fE2, and Pg and higher SHBG levels in both ovarian phases for pts vs controls
No significant changes in hormone levels and in prevalence of anovulatory cycles between pts grouped by seizure frequency
Luteal fE2 and Pg levels chiefly impaired in women with more frequent seizures, mostly undergoing AED polytherapies, but not in pts with absent or rarer seizures for pts vs controls

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