Your Article Summary
See Latest ArticlesRapid oral transmucosal absorption of sumatriptan, and pharmacodynamics in acute migraine
Headache: The Journal of Head and Face Pain, 06/25/09
Dilone E et al. – The initial pharmacokinetics of lingual spray (LS) approximate to those of subcutaneous injection, despite some fraction of swallowed dose. These pharmacokinetics correspond with earlier effectiveness of LS compared with a 50-mg sumatriptan tablet, and at lower dose, in an enriched, relevant pt population.
Methods- Study of whether sumatriptan is absorbed across oral mucosa
- Description of pharmacokinetics
- Evaluation of potential pharmacodynamic correlates of such pharmacokinetics in pts with migraine attacks
- Clinical trial 1: comparison of pharmacokinetic performance of sumatriptan LS formulation (2 dose sizes, 1 in both fed/fasted state) vs orthodox 50-mg sumatriptan tablet in normal volunteers
- Clinical trial 2: multiple-attack, crossover, fixed dose-order, open-label comparison of sumatriptan LS (up to 3 different dose sizes) vs 100-mg sumatriptan tablet for pt population enriched by documenting suboptimal response to initial 50-mg sumatriptan tablet
- LS formulations resulted in double-peaked time-plasma concentration curves consistent with absorption of sumatriptan across oral mucosa
- First Tmax usually ~10-15 min
- In enriched pt population, first Tmax corresponded with evidence of earlier efficacy for LS vs 50-mg tablet
- Lower dose size for former consistent with oral mucosal drug absorption and evasion of first-pass metabolism
Today in Headache...keeping you current
Receive free subspecialty "5-minute updates" via email
Escitalopram and Venlafaxine for the Prophylaxis of Migraine Headache Without Mood Disorders
Clinical Neuropharmacology, 10/02/09
Tension-type Headache in the Elderly
Current Pain and Headache Reports, 11/06/09
Occipital Nerve Blocks: Effect of Symptomatic Medication
Headache: The Journal of Head and Face Pain, 11/05/09
Today in Neuro/Psych pharmacology...keeping you current
Receive free subspecialty "5-minute updates" via email
Outcome of intracerebral haemorrhage patients pre-treated with statins
European Journal of Neurology, 11/17/09
Cardiometabolic Risk of Second-Generation Antipsychotic Medications During First-Time Use in Children and Adolescents
JAMA, 10/29/09
Statin use and neurologic morbidity after coronary artery bypass grafting. A cohort study
Neurology, 11/16/09