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α-synuclein, alcohol use disorders, and Parkinson's disease: A case–control study
Parkinsonism & Related Disorders, 06/26/09

Brighina L et al. – Findings suggest that α-synuclein gene promoter (SNCA REP1) genotype and alcohol use disorders are independently associated with Parkinson disease (PD).

Methods

Study to clarify association patterns between REP1 genotype, alcohol use disorders, and PD
Cases recruited from Mayo Clinic Neurology Department; 893 case–control pairs
Controls: unaffected sibling controls and unrelated controls
Assessment of alcohol use via a structured phone interview
Screen for alcohol use disorders by CAGE questionnaire
REP1 genotyping with ABI 3730XL platform

Results

Increasing risk of PD with increasing SNCA REP1 allele length
Decreasing risk of PD with increasing CAGE score
Association of REP1 score with PD remained significant after adjusting for CAGE score
Association of CAGE score with PD remained significant after adjusting for REP1 score
No pairwise interactions

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