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Age of Onset in Concordant Twins and Other Relative Pairs With Multiple Sclerosis
American Journal of Epidemiology, 06/24/09

Sadovnick DA et al. - Dizygotic twins resembled monozygotic twins more than siblings. The age-of-onset correlation for maternal half siblings was higher than that for paternal half siblings, consistent with other observations suggesting an intrauterine environmental effect on multiple sclerosis risk. Intergenerational comparisons are complicated by substantial increases of multiple sclerosis incidence over time. Genetic loading (familial vs. sporadic cases) did not generally influence the age of onset, but correlation of age of onset in multiple sclerosis relative pairs was proportional to genetic sharing. A maternal parent-of-origin effect on the age of onset in collinear generations was suggested.

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