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The vascular risk associations with migraine: Relation to migraine susceptibility and progression
Atherosclerosis, 06/30/09

Hamed SA et al. – A review of the vascular risk associations with migraine summarizes the relationship to migraine susceptibility and progression. Understanding of migraine as a risk for vascular diseases raises important clinical implications, recommendations, and future perspectives in migraine treatment and prevention.

Methods

Review of vascular risk associations with migraine

Results

Changes in cortical excitability, neuroinflammation and dysfunction of the vascular wall contribute to migraine pathophysiology
Prolonged repeat migraine result in inflammatory arteriopathy of cranial vessels
Migraine may be associated with special pattern of inflammatory markers and some adverse vascular risk factors
Risk factors: increased levels of CRP, ILs, TNF-alpha and adhesion molecules
Factors serve as markers of systemic inflammation, oxidative stress and thrombosis, increased body weight, high blood pressure, hypercholesterolemia, impaired insulin sensitivity, high homocysteine levels, stroke, and coronary heart disease

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