Neurology Medical News about estrogens following ischemic stroke;neuroprotective effects

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Neuroprotective effects of estrogens following ischemic stroke
Frontiers in Neuroendocrinology, 06/24/09

Suzukia S et al. – A review of the current understanding of neuroprotective actions of estrogens against ischemic stroke discusses the implications for improving quality of life in aging populations.

Methods

Review of neuroprotective effects of estrogens following ischemic stroke
Study of whether and how 17beta-estradiol (E2) protects the brain against neurodegeneration associated with cerebrovascular stroke

Results

Low, physiologic concentrations of E2 dramatically protect brain against stroke injury
Multiple signaling pathways and key genes mediate protective action of E2
E2 concentrations strikingly similar to low-basal circulating levels in cycling mice

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