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Impact of sex steroids on neuroinflammatory processes and experimental multiple sclerosis
Frontiers in Neuroendocrinology, 06/24/09

Kipp M et al. – A review of the impact of sex steroids on neuroinflammatory processes and experimental multiple sclerosis summarizes results of in vitro studies and experimental animal models and surveys the literature.

Methods

Review of sex steroids impact on neuroinflammatory processes and experimental multiple sclerosis

Results

Synthetic and natural estrogens as well as progestins modulate neuronal development and activity
Steroids attenuate neuroinflammation by reducing pro-inflammatory property of astrocytes
Variable effect based on brain region and toxic condition
Both hormones can individually mediate protection, with more effective cooperation
Animal model for multiple sclerosis shows steroids achieve remyelination after demyelination
Cellular mechanisms involve interactions with astroglia, insulin-like growth factor-1 responses, and recruitment of oligodendrocytes

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