Your Article Summary
See Latest ArticlesCombination treatment with progesterone and vitamin D hormone may be more effective than monotherapy for nervous system injury and disease
Frontiers in Neuroendocrinology, 06/24/09
Cekic M et al. – A review summarizes pre-clinical research and two recent clinical trials and reports that combination treatment with progesterone (PROG) and vitamin D hormone may be more effective than monotherapy for traumatic brain injury (TBI) and disease.
Methods- Review of progesterone and vitamin D hormone as combination treatment vs monotherapy for nervous system injury and disease
- PROG and its metabolites exert beneficial effects after TBI via metabolic and physiological pathways to reduce damage in different tissues and organ systems
- Emerging data show 1,25-dihydroxyvitamin D3 (VDH) as a neuroprotective steroid hormone, its pathways differ from PROG
- VDH and PROG: high safety profiles, act on many different injury and pathological mechanisms; clinically relevant; easy to administer; inexpensive
- Vitamin D deficiency is highly prevalent, especially in elderly and institutionalized pts, and can significantly affect recovery after CNS injury
Related Articles
Vitamin D association with estradiol and progesterone in young women
Cancer Causes and Control, 11/25/09
Relevance Score: 90%
Vitamin D compounds for people with chronic kidney disease requiring dialysis
Cochrane Reviews, 10/20/09
Relevance Score: 83%
Vitamin D and cardiovascular disease
Current Atherosclerosis Reports, 11/12/09
Relevance Score: 81%
A phase 2 trial exploring the effects of high-dose (10,000 IU/day) Vitamin D3 in breast cancer patients with bone metastases
Cancer, 11/25/09
Relevance Score: 80%
Heart and bone damage from low vitamin D tied to declines in sex hormones
EurekAlert, 11/16/09
Relevance Score: 80%
Today in Neuroendocrinology...keeping you current
Receive free subspecialty "5-minute updates" via email
Evaluation of antioxidant systems in pituitary-adrenal axis diseases
Pituitary, 12/18/09
A heritable predisposition to pituitary tumors
Pituitary, 12/18/09
The risk for breast cancer is not evidently increased in women with hyperprolactinemia
Pituitary, 12/18/09