Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. 2008 Exclusive Survey—Earnings: Good news for primary care income 3. Medicare pay-for-reporting effort draws fire from frustrated doctors 4. Debunking Myths in the US Healthcare System 5. Doctors and the DEA Free full text
Top Ten Searches
parkinson's neuritis neuralgia myasthenia gravis lactic acidosis ataxia seizure tinnitus migraine hypotoniaYour Article Summary
See Latest ArticlesNew insights on the neuroprotective role of sterols and sex steroids: The seladin-1/DHCR24 paradigm
Frontiers in Neuroendocrinology, 06/26/09
Peri A et al. – A review describes how the protein seladin-1/DHCR24 interacts with cholesterol and estrogens, thus generating a neuroprotective network that may aid in prevention/treatment of neurodegenerative diseases.
Methods- Review of the neuroprotective role of seladin-1/DHCR24
- Seladin-1 (for selective Alzheimer’s disease indicator-1) identified as downregulated in vulnerable brain regions in Alzheimer’s disease
- Based on anti-apoptotic properties, seladin-1 considered a novel neuroprotective factor
- Seladin-1 corresponds to gene encoding 3-beta-hydroxysterol delta-24-reductase (DHCR24), which catalyzes synthesis of cholesterol from desmosterol
- Cholesterol plays a fundamental role in maintaining brain homeostasis
- Based on enzymatic activity, seladin-1/DHCR24 considered as human homolog of the plant protein DIMINUTO/DWARF1 involved in synthesis of sterol plant hormones
- Seladin-1/DHCR24 is a fundamental mediator of estrogen protective effects in the brain
Related Articles
Activational effects of sex hormones on cognition in men
Clinical Endocrinology, 10/16/09
Relevance Score: 67%
Kisspeptin/GPR54 system as potential target for endocrine disruption of reproductive development and function
International Journal of Andrology, 11/13/09
Relevance Score: 66%
Sex Steroid Hormones, Hormonal Contraception, and the Immunobiology of Human Immunodeficiency Virus-1 Infection
Endocrine Reviews, 11/11/09
Relevance Score: 66%
Gender-Specific Prevalences of Fatty Liver in Obese Children and Adolescents: Roles of Body Fat Distribution, Sex Steroids, and Insulin Resistance
Journal of Clinical Endocrinology and Metabolism, 10/12/09
Relevance Score: 66%
Attenuated Sex Steroid Receptor Expression in Fallopian Tube of Women with Ectopic Pregnancy
Journal of Clinical Endocrinology and Metabolism, 11/11/09
Relevance Score: 65%
Today in Neuroendocrinology...keeping you current
Receive free subspecialty "5-minute updates" via email
Neuroendocrine carcinomas arising in solid-organ transplant recipients: rare but aggressive malignancies
Oncology (Karger), 11/25/09
ZM447439, a Novel Promising Aurora Kinase Inhibitor, Provokes Antiproliferative and Proapoptotic Effects Alone and in Combination with Bio- and Chemotherapeutic Agents in Gastroenteropancreatic Neuroendocrine Tumor Cell Lines
Neuroendocrinology, 11/24/09
Recurrence of Hyperprolactinemia after Withdrawal of Dopamine Agonists: Systematic Review and Meta-Analysis
Journal of Clinical Endocrinology and Metabolism, 11/20/09
Sponsor
Article Search
Sponsor