Neurology Medical News about acute seizure management of children;intravenous Levetiracetam

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Role of intravenous levetiracetam in acute seizure management of children
Pediatric Neurology , 06/24/09

Kirmani BF et al. – Intravenous (IV) levetiracetam can be used adjunctively or as monotherapy in children with status epilepticus and acute exacerbation of seizures.

Methods

Status epilepticus defined as seizure duration >30 minutes
Retrospective study of data from children treated with IV levetiracetam for status epilepticus and acute exacerbation of seizures
Data retrieval from institution's electronic medical records for status epilepticus pts with acute exacerbation of seizures who received IV levetiracetam

Results

Levetiracetam load of 25-50 mg/kg for 32 status epilepticus pts: age 2 mo-18 yrs; 17 (53.1%) males; 15 (46.8%) females
Favorable response to IV levetiracetam for all pts
Status epilepticus ceased clinically and electrographically
IV levetiracetam after fosphenytoin and Ativan with no response for 18 pts (56.5%)
No serious side effects reported
Discharge on levetiracetam monotherapy for 15 pts (46.8%)
Levetiracetam as adjunctive therapy after hospital discharge for 9 (28.1%) pts

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