Neurology Medical News about Narcolepsy; Baclofen; Sodium Oxybate

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Narcolepsy: Action of Two gamma-Aminobutyric Acid Type B Agonists, Baclofen and Sodium Oxybate
Pediatric Neurology , 06/23/09

Huang Y-S et al. - The dose of baclofen demonstrating an effect on nocturnal sleep without negative side effects was determined and maintained. Both drugs increased total sleep time and delta waves during sleep, but only sodium oxybate had an effect on daytime sleepiness and cataplexy at 3 months. Improvement of total nocturnal sleep time had no beneficial effect on daytime sleepiness. The mechanism by which sodium oxybate improves cataplexy and sleepiness is inferred to be due to properties beyond direct GABAB agonist action.

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Anxiety and mood disorders in narcolepsy: a case-control study
General Hospital Psychiatry, 10/07/09 Relevance Score: 87%

A brain PET study in patients with narcolepsy-cataplexy
Journal of Neurology, Neurosurgery, and Psychiatry, 11/17/09 Relevance Score: 85%

Multiple sleep latency measures in narcolepsy and behaviourally induced insufficient sleep syndrome
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Mayo Clinic Proceedings Publishes Study of NUVIGIL in Patients with Shift Work Disorder
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