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CSF oligoclonal band patterns reveal disease heterogeneity in multiple sclerosis
Journal of Neuroimmunology, 06/23/09

Villar LM et al. - The authors studied oligoclonal bands in 424 MS patients. Most primary progressive (PPMS) patients showed serum OCGB with additional bands in CSF. Conversely, most RRMS and secondary progressive (SPMS) patients showed OCGB exclusively in CSF. Moreover, no PPMS patient presented LS-OCMB, while 31% of RRMS and 60% of SPMS groups showed these antibodies. This suggests heterogeneous autoimmune mechanisms in MS.

Exclusive Author Commentary
Luisa M. Villar, 06/24/09

These findings contribute to identificate of the different autoimmune responses occurring in relapsing-remitting and primary progressive MS. Their complete understanding will enable more specific treatment approaches in this disease.

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