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The Val66Met polymorphism in the BDNF gene is associated with epilepsy in fragile X syndrome
Epilepsy Research, 06/25/09

Louhivuori V et al. - The Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene may modulate the epilepsy phenotype. The authors investigated the impact of polymorphisms in the BDNF gene on clinical features in fragile X syndrome (FXS). In this study sample, the Met66 allele associated with epilepsy of finnish FXS men. Abnormalities in BDNF-mediated plasticity are shown in FXS and the present data suggest that the Met66 allele might predispose FXS males to epilepsy.

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