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Addition of verapamil in the treatment of severe myoclonic epilepsy in infancy
Epilepsy Research, 06/23/09
Iannetti P et al. - The authors report on the use of the voltage-gated calcium channel blocker (Vg-CCB), verapamil, as an add-on anticonvulsant medication in two girls, 4 and 14 years of age, who were affected by severe myoclonic epilepsy in infancy (SMEI) or Dravet syndrome, a channelopathy caused by abnormalities in the voltage-gated sodium channel neuronal type ?1 subunit (SCN1A) gene at 2q24... This is the first report on long-lasting verapamil therapy in SMEI. The functional consequences of such in vivo modulating effects on Ca++ channels could contribute to rational targeting for future molecular therapeutic approaches in pharmacoresistant epileptic channelopathies.
Today in Pediatric Neurology...keeping you current
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Stimulation threshold potentials of intraoperative cortical motor mapping using monopolar trains of five in pediatric epilepsy surgery
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Today in Seizure...keeping you current
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Stimulation threshold potentials of intraoperative cortical motor mapping using monopolar trains of five in pediatric epilepsy surgery
Child's Nervous System, 12/18/09
Probable levetiracetam-associated depression in the elderly: Two case reports
The American Journal of Geriatric Pharmacotherapy, 12/18/09
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