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See Latest ArticlesRestless legs syndrome: differential diagnosis and management with pramipexole
Clinical Interventions in Aging, 06/19/09
Brindani F et al. - Current understanding of the pathophysiology of RLS points to the involvement of three interrelated components: dopaminergic dysfunction, impaired iron homeostasis, and genetic mechanisms. The diagnosis of RLS is made according to the consensus criteria by a National Institutes of Health panel: 1) an urge to move the legs, usually accompanied by uncomfortable sensations; 2) beginning or worsening during rest; 3) relieved by movement; and 4) worse, or only occurring, in the evening or at night. The presence of neuropathy should be especially investigated in nonhereditary, late-onset RLS, in view of a possible treatment of the underlying disease. The first line treatment for idiopathic RLS is represented by dopamine agonists, in particular nonergot-derived ropinirole and pramipexole, whereas ergot dopamine agonists (cabergoline and pergolide) are no longer in first-line use given the risks of cardiac valvulopathy. Although no comparative trials have been published, a meta-analysis of pramipexole versus ropinirole suggests differences in efficacy and tolerability favoring pramipexole.
Today in Movement Disorders...keeping you current
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Severe relapses after the first infusion of natalizumab in active relapsing-remitting multiple sclerosis
Multiple Sclerosis, 10/09/09
Paraplegia Following Image-Guided Transforaminal Lumbar Spine Epidural Steroid Injection: Two Case Reports
Pain Medicine, 10/29/09
The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort
Brain, 10/09/09
Today in Neuropathy/Myopathy...keeping you current
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Nortriptyline and gabapentin, alone and in combination for neuropathic pain: a double-blind, randomised controlled crossover trial
The Lancet, 10/13/09
Amitriptyline vs. pregabalin in painful diabetic neuropathy: a randomized double blind clinical trial
Diabetic Medicine, 10/01/09
A Randomised Placebo Controlled Double Blind Clinical Trial of Cannabis Based Medicinal Product (Sativex) in Painful Diabetic Neuropathy: Depression is a Major Confounding Factor
Diabetes Care, 10/09/09
Today in Sleep...keeping you current
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Armodafinil for Treatment of Excessive Sleepiness Associated With Shift Work Disorder: A Randomized Controlled Study
Mayo Clinic Proceedings, 11/03/09
Validation of ECG-derived sleep architecture and ventilation in sleep apnea and chronic fatigue syndrome
Sleep and Breathing, 10/15/09
Review: continuous positive airway pressure devices are effective and cost-effective for obstructive sleep apnoea
Evidence-Based Medicine, 10/22/09
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