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Influences on seizure activity in pregnant women with epilepsy
Epilepsy and Behavior, 06/23/09
Sabers A et al. – Results suggest, with methodologic limitations, that women followed in a specialized epilepsy clinic have a lower risk of seizure deterioration during pregnancy vs pts referred after conception.
Methods- Study of whether referral to a specialized epilepsy clinic prior to pregnancy influences seizure activity during pregnancy
- Use of pre-pregnancy folic acid supplementation as a marker of intent to conceive
- Evaluation of whether folic acid use at time of conception correlates with risk of seizure deterioration in pregnancy
- Subjects: group 1: 46 pts followed in specialized epilepsy clinic before conception; group 2: 44 pts referred to clinic after pregnancy diagnosed
- Seizure deterioration significantly lower in group 1 (9%) vs group 2 (32%)
- Likelihood of folic acid supplementation significantly higher in group 1
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