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See Latest ArticlesDeep brain stimulation of the subthalamic nucleus improves intrinsic alertness in Parkinson's disease
Movement Disorders, 06/19/09
Fimm B et al. – Findings suggest that deep brain stimulation (DBS) modulates the frontoparietal network of alertness.
Methods- Study of 13 pts with Parkinson's disease (PD) and bilateral DBS of the subthalamic nucleus (STN)
- Use of a wide range of neuropsychological tasks to switch DBS on/off
- Tasks: reasoning, cognitive flexibility, phonemic/semantic word fluency, verbal/nonverbal short-term memory, learning, delayed verbal memory recall, and stimulus-response incompatibility
- Focus on basic attentional functions, in particular intrinsic and phasic alertness and visual search
- DBS significantly improved intrinsic alertness
- DBS did not affect phasic alertness and other neuropsychological domains
- DBS effects on intrinsic alertness independent of motor improvements
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