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An introduction to migraine pathophysiology
Techniques in Regional Anesthesia and Pain Management, 06/26/09

Benoit DP - There are many suggested possibilities for the pathogenesis of migraine. Key to fully explaining its pathogenesis is to encompass the wide neurological effects it has on the body. Cortical spreading depression and abnormal brain stem activity clearly are involved, but it is still unknown what the earliest changes are during the evolution of an attack. Likely there are other pathways involved that modulate the process. What is exciting is the ongoing bench work and translational research that has led to a better understanding of pathophysiology, which is key to effective treatment and likely why there are more treatments for migraineurs today than ever before.

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