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A sensitive, noise-resistant method for identifying focal demyelination and remyelination in patients with multiple sclerosis via voxel-wise changes in magnetization transfer ratio
Journal of the Neurological Sciences, 06/22/09
Dwyer M et al. - The proposed method provides a valuable means for quantifying MS-related tissue changes, particularly demyelination and remyelination, in vivo and without the use of highly complex or experimental MRI acquisition techniques. It improves on the sensitivity of other approaches, and may increase the statistical power of studies investigating the effects of therapy on MRI outcomes in MS.
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