Neurology

Your Article Summary

See Latest Articles

Origin of pain in migraine: Evidence for peripheral sensitization
The Lancet Neurology, 06/17/09

Olesen J et al. – An editorial review of evidence for peripheral sensitization in the origin of migraine pain focuses on activation of peripheral nociceptors. Migraine may be explained to pts as a brain disorder with headache originating in sensory fibers that convey pain signals from intracranial and extracranial blood vessels.

• Summary of evidence and viewpoint on peripheral sensitization in migraine pain origin

• Despite evidence for the role of central sensitization in migraine pathophysiology, neuronal hyperexcitability may depend on activation of peripheral nociceptors
• Although migraine onset may occur deep-brain structures, some evidence indicates that the headache phase depends on nociceptive input from perivascular sensory nerve terminals
• Evidence for input from extracranial, dural, and pial arteries as well as evidence against these locations
• Afferents are probably excited in all 3 territories or importance of individual territories varies among pts

Related Articles

See all related articles

Topiramate in migraine progression
The Journal of Headache and Pain, 10/21/09    Relevance Score: 96%

CSD, BBB and MMP-9 elevations: animal experiments versus clinical phenomena in migraine
Expert Review of Neurotherapeutics, 11/12/09    Relevance Score: 94%

Aura migraines : Aura migraines double stroke risk
Internet Source, 11/02/09    Relevance Score: 94%

Migraine Chronification - Concept and Risk Factors
Discovery Medicine, 10/27/09    Relevance Score: 94%

Normal Cortical Energy Metabolism in Migrainous Stroke. A 31P-MR Spectroscopy Study
Stroke, 10/20/09    Relevance Score: 94%

Today in Headache...keeping you current

Receive free subspecialty "5-minute updates" via email

Visual noise selectively degrades vision in migraine
Investigative Ophthalmology and Visual Science, 12/18/09

Developmental changes of the contingent negative variation in migraine and healthy children
The Journal of Headache and Pain, 12/18/09

Auditory Brainstem Evoked Responses In Migraine Patients
The Internet Journal of Neurology, 12/18/09

 See all of Headache

Today in Neurosensory Disorders...keeping you current

Receive free subspecialty "5-minute updates" via email

Non-audiofacial morbidity after Gamma Knife surgery for vestibular schwannoma
Neurosurgical Focus, 12/17/09

Evaluation of hearing function after Gamma Knife surgery of vestibular schwannomas
Neurosurgical Focus, 12/16/09

Olfactory dysfunction as a diagnostic marker for Parkinson’s disease
Expert Review of Neurotherapeutics, 12/15/09

 See all of Neurosensory Disorders