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See Latest ArticlesMemantine in patients with Parkinson's disease dementia or dementia with Lewy bodies: A double-blind, placebo-controlled, multicentre trial
The Lancet Neurology, 06/17/09
Aarsland D et al. – Pts with dementia with Lewy bodies (DLB) or Parkinson's disease dementia (PDD) may benefit from treatment with the N-methyl D-aspartate (NMDA) receptor antagonist memantine, pending confirmation of preliminary findings by large-scale studies. Treatment with memantine was well tolerated.
Methods- Study of safety and efficacy of memantine in pts with PDD or DLB
- Parallel-group, 24-week, randomized controlled study of memantine (20 mg/day) vs placebo at 4 psychiatric and neurologic outpatient clinics in Norway, Sweden, and the UK during 2005-2008
- Subjects fulfilled UK Parkinson's Disease Society Brain Bank clinical diagnostic criteria for PD and developed dementia (PDD) by DSM IV criteria ≥1 yr after onset of motor symptoms or met revised consensus operationalized criteria for DLB
- Physicians masked to pt treatment allocation
- Primary outcome measure: clinical global impression of change (CGIC), ranging from 1-7 points; low score = better outcome
- Treatment for 72 pts with PDD or DLB: 34 with memantine and 38 with placebo
- Study completion by 56 (78%)
- All withdrawals due to adverse events; similar proportion of withdrawals for both groups
- At wk 24, memantine pts had better CGIC scores vs placebo pts
- Except improved speed on attentional tasks in memantine pts, no significant differences between groups in secondary outcome measures
Today in Dementia...keeping you current
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The Clinical Course of Advanced Dementia
New England Journal of Medicine, 10/16/09
Memantine versus donepezil in mild to moderate Alzheimer's disease: a randomized trial with magnetic resonance spectroscopy
European Journal of Neurology, 11/02/09
Memantine: a review of studies into its safety and efficacy in treating Alzheimer’s disease and other dementias
Clinical Interventions in Aging, 09/29/09
Today in Movement Disorders...keeping you current
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Today in Neuro/Psych pharmacology...keeping you current
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Escitalopram and Venlafaxine for the Prophylaxis of Migraine Headache Without Mood Disorders
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Nortriptyline and gabapentin, alone and in combination for neuropathic pain: a double-blind, randomised controlled crossover trial
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Cardiometabolic Risk of Second-Generation Antipsychotic Medications During First-Time Use in Children and Adolescents
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