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See Latest ArticlesDrug consumption in medication overuse headache is influenced by brain-derived neurotrophic factor Val66Met polymorphism
The Journal of Headache and Pain, 06/16/09
Di Lorenzo C et al. – Findings show an influence of the common 196G > A single-nucleotide polymorphism of BDNF gene, resulting in a valine 66 to methionine (Val66Met).
Methods- Study to identify a worsening factor in MOH, vs detection of a specific risk factor for disease development
- Investigation of whether presence of a functional BDNF polymorphism determines clinical differences within a group of 90 MOH pts, particularly in monthly drug consumption
- Direct comparison of MOH pts homozygous for G allele (G/G) with carriers of A allele (non-G/G)
- Observation of 47 G/G genotypes and 60 non-G/G genotypes
- Higher consumption of monthly drug number for non-G/G vs G/G pts
- On multiple regression analysis, the Val66Met BDNF polymorphism was a significant independent predictor of analgesic drug consumption
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