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See Latest ArticlesMolecular advances of brain tumors in radiation oncology
Seminars in Radiation Oncology, 06/12/09
Noda S et al. – A review presents new, targeted therapies in context of current treatment options for glioblastoma pts.
Methods- Review of molecular advances of brain tumors in radiation oncology
- Glioblastoma: WHO classification as grade IV malignant glioma based on the World Health Organization; most common primary brain tumor in adults
- Average survival: <1 yr; no notable improvements over past 3 decades
- Traditional therapy: surgery and radiotherapy provide palliative benefit vs the marginal, controversial value of chemotherapy
- Dismal prognosis due to radioresistance
- Despite genetic heterogeneity of malignant gliomas, common aberrations in elements of growth and survival pathways
- New treatments target molecules in signaling pathways with goal to increase specific efficacy and minimize toxicity
- Most common classes of agents in targeted cancer treatment: monoclonal antibodies and low molecular-weight kinase inhibitors
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