Neurology Medical News about Parkinsons disease;functional impariment;dopaminergic striatal projection

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Substantia nigra echogenicity: A structural correlate of functional impairment of the dopaminergic striatal projection in Parkinson's disease
Movement Disorders, 06/15/09

Weise D et al. – Findings support the hypothesis that in Parkinson's disease (PD) abnormal extension of echogenic substantia nigra (SN) area provides a direct structural marker of degeneration of SN neurons. Thus, in PD, transcranial sonography (TCS), and I-123-2-beta-carbomethoxy-3-beta-(4-iodophenyl)-tropane (-CIT) assess pathophysiologically related phenomena.

Methods

Study to clarify the relationship between sonographic abnormalities of SN and dysfunction of striatal dopaminergic neurotransmission
Assessment of 50 PD pts
Comparison of the spatial extension of the echogenic SN area with activity of presynaptic striatal dopamine reuptake transporters
Assessement in the same pts by -CIT single-photon emission computed tomography (SPECT)

Results

Extension of echogenic SN area correlated (inversely) with striatal activity of presynaptic dopamine reuptake transporter in PD pts and with the equivalent levodopa dose

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