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Evaluation of efficacy and safety of anterior corpus callosotomy with keyhole in refractory seizures
Seizure - European Journal of Epilepsy, 06/12/09

Ping Z et al. – Anterior corpus callosotomy with a keyhole approach produces highly favorable outcomes for both generalized tonic–clonic seizures (GTCSs) and atonic or tonic seizures with a low risk for complications.

• Study of the efficacy and safety of anterior corpus callosotomy with a keyhole approach on refractory seizures
• Evaluation of this procedure for drop attacks (DAs) and GTCSs
• Anterior corpus callosotomy for all 31 refractory seizure pts without other epilepsy surgery
• Assessment for seizure response and procedure complications

• Seizure types: 26 GTCS; 9 atonic or tonic seizures with DA
• GTCS pts, 84.6% had ≥50% decrease in seizure frequency; 61.5% had ≥80% reduction
• DA pts: 77.8% had ≥50% decrease in seizure frequency; 55.6% had ≥80% reduction
• No statistically significant differences between the groups in final efficacy
• Overall complication rate for corpus callosotomy: 12.9%
• Permanent complication rate: 3.2%

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