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Overweight in midlife and risk of dementia: A 40-year follow-up study
International Journal of Obesity, 06/19/09

Hassin LB et al. – Findings support increased risk for later dementia in midlife overweight pts. The risk is increased for both Alzheimer's disease and vascular dementia, with same pattern for men and women.

• Study of whether overweight status in midlife increases dementia risk later in life
• Assessment of body mass index in 1152 Swedish Twin Registry subjects age 45–65 yrs in 1963
• Pts later screened for dementia in prospective study with up to 40-yr follow-up
• Dementia diagnosis for 312 pts
• Logistic regression analyses adjusted for demographic factors, smoking/alcohol habits

• On adjusted analyses men and women categorized as overweight in midlife had elevated risk of dementia, Alzheimer's disease, and vascular dementia
• Further adjustments for diabetes and vascular diseases did not substantially affect associations, except for vascular dementia, reflecting significance of diabetes and vascular diseases in etiology of vascular dementia
• No significant interaction between overweight and APOE alt epsilon4 status, indicating that having both risk factors does not have a multiplicative effect with regard to dementia risk

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