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Chronic glucocorticoid hypersecretion in Cushing’s syndrome exacerbates cognitive aging
Brain and Cognition, 06/12/09

Michaud K et al. - These results suggest that hypersecretion of GCs has “aging-like” effects on cognitive performance in individuals with CS.

• Ten subjects with CS were compared to sex-, age-, and education-matched healthy controls and older subjects (age of CS subjects + 15 yr).
• All participants were administered tests to assess attention, visuospatial processing, learning and memory, reasoning, concept formation and verbal fluency.

• MANCOVAs with depression scores as covariate and polynomial contrasts revealed that the age-matched control group performed better than the CS and older subject groups in visual target detection, trail making test, stroop task, digit symbol substitution, block design, object assembly, visual reproduction, spatial memory and similarities.
• The CS and older subjects performed similarly on these tasks.
• A principal component analysis revealed two significant factors, representing general cognitive function and verbal memory explaining 39.9% and 10.0% of the variance, respectively.
• Additional MANCOVAs with depression as a covariate revealed that CS and older control subjects showed impaired performance on general cognitive function compared to age-matched controls.

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