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See Latest ArticlesCluster headache and alpha 1-antitrypsin deficiency
Cephalalgia, 06/16/09
Summ O et al. – The presence of an S or Z allele is associated with higher attack frequency in cluster headache (CH).
Methods- Study of possible associations between common genotypes of the SERPINA1 gene and CH
- Subjects: 55 CH pts and 55 controls
- Analysis of alpha 1-antitrypsin (alpha 1-AT) levels in serum and the genotype
- Assessment of pt CH characteristics
- No association found between CH and a genotype not matching the homozygous wild type for alpha-1-AT
- Significant difference of CH attack frequency in pts who are heterozygous or homozygous M allele carriers
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