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Atherosclerotic disease of the proximal aorta and the risk of vascular events in a population-based cohort. The Aortic Plaques and Risk of Ischemic Stroke (APRIS) Study
Stroke, 06/09/09

Russo C et al. – A population-based cohort shows that the incidental detection of plaques in the aortic arch or proximal descending aorta was not associated with future vascular events. Associated cofactors may affect the previously reported association between proximal aortic plaques and vascular events.

• Study of whether proximal aortic plaques are associated with vascular events in a community-based cohort
• Evaluation of Stroke-free subjects from the Aortic Plaques and Risk of Ischemic Stroke (APRIS) study
• Assessment of aortic arch and proximal descending aortic plaques by transesophageal echocardiography (TEE)
• Prospective review of vascular events (myocardial infarction, ischemic stroke, vascular death); assessment of association with aortic plaques

• 209 subjects were studied (age 67.0±8.6 years). Aortic arch plaques were present in 130 subjects (62.2%), large plaques (≥4 mm) in 50 (23.9%)
• Descending aortic plaques in 126 subjects (60.9%), large plaques in 41 (19.8%)
• During follow-up of 74.4±26.3 mo, 29 events occurred (12 myocardial infarctions, 11 ischemic strokes, 6 vascular deaths)
• After adjustment for risk factors, large aortic arch plaques not associated with combined vascular events or ischemic stroke
• Large descending aortic plaques not independently associated with vascular events or ischemic stroke

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