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Human immunodeficiency virus type 1 in the central nervous system leads to decreased dopamine in different regions of postmortem human brains
Journal of Neurovirology, 06/15/09
Kumar AM et al. - A majority of HIV-1+ individuals had variable degrees of neurocognitive impairments, but no specific relationship was found between the regional DA content and severity of neurocognitive deficits. These findings suggest widespread deficits in dopamine in different brain regions of HIV-1-infected cases, and that these deficits may be the results of HIV-1-induced neurodegeneration in the subcortical regions of human brain.
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