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Mechanically Induced Reactive Gliosis Causes ATP-Mediated Alterations in Astrocyte Stiffness
Journal of Neurotrauma, 06/15/09
Miller WJ et al. - Alterations in astrocyte stiffness in the area of injury and mechanical penumbra were ameliorated by pretreating cultures with a nonselective P2 receptor antagonist (PPADS). Since neuronal cells generally prefer softer substrates for growth and neurite extension, these findings may indicate that the mechanical characteristics of reactive astrocytes are favorable for neuronal recovery after traumatic brain injury.
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