Your Article Summary
See Latest ArticlesCognitive effects of pegylated interferon in individuals with primary brain tumors
Journal of Neuro-Oncology, 06/04/09
Dickinson MD et al. - In a trial to assess the cognitive effects of pegylated interferon in brain tumor pts, it was found that participants may not have been starting at their baseline cognitive status and the potential neurotoxic effects of interferon may have been obscured by prior treatments. An alternative explanation is that treatment with pegylated interferon did not produce further impairment and pts experienced stability in their cognitive functioning.
Methods- Participants in this study were 35 primary brain tumor pts who received pegylated interferon at tumor recurrence.
- A neuropsychological battery assessed verbal memory, executive functioning, attention, information processing speed, and language functioning.
- Individual growth curve analyses were used to estimate cognitive change throughout treatment with interferon.
- Results revealed performance declined on a task of psychomotor speed and upper extremity dexterity.
- Although decline in a few tests was found, its degree may have been reduced because individuals were tested after tumor recurrence where a substantial amount of cognitive change had already potentially occurred due to surgery, radiation therapy, and chemotherapy.
Related Articles
Psychological interventions for reducing pain and distress during routine childhood immunizations: A systematic review
Clinical Therapeutics, 10/16/09
Relevance Score: 69%
The effects of cognitive training on community-dwelling elderly Koreans
Journal of Psychiatric and Mental Health Nursing, 11/16/09
Relevance Score: 68%
The cognitive effects of chemotherapy in post-menopausal breast cancer patients: a controlled longitudinal study
Breast Cancer Research and Treatment, 11/12/09
Relevance Score: 68%
The Effect of Strict Volume Control on Cognitive Functions in Chronic Hemodialysis Patients
Renal Failure, 10/22/09
Relevance Score: 67%
Prevention of dementia by antihypertensive drugs: how AT1-receptor-blockers and dihydropyridines better prevent dementia in hypertensive patients than thiazides and ACE-inhibitors
Expert Review of Neurotherapeutics, 10/08/09
Relevance Score: 67%
Today in Neurologic Oncology...keeping you current
Receive free subspecialty "5-minute updates" via email
Genomic Landscape of Meningiomas
Brain Pathology, 12/15/09
Phase II trial of erlotinib with temozolomide and radiation in patients with newly diagnosed glioblastoma multiforme
Journal of Neuro-Oncology, 12/15/09
Control of brain metastases using frameless image-guided radiosurgery
Neurosurgical Focus, 12/15/09