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See Latest ArticlesEndocan expression and localization in human glioblastomas
Journal of Neuropathology and Experimental Neurology, 06/04/09
Maurage CA et al. – Results suggest that endocan is associated with abnormal vasculature in high-grade gliomas.
Methods- Immunohistochemical analysis of endocan expression in 82 brain tumors
- Endocan immunoreactivity in hyperplastic endothelial cells in high-grade gliomas, mostly at tumor margins
- Endothelial cells mostly endocan negative in low-grade gliomas
- Endocan never detected in cerebral cortex distant from tumors
- Tumor cells in high- but not low-grade gliomas expressed endocan
- Endocan found in palisading cells surrounding areas of necrosis in glioblastomas
- Endothelial cell endocan immunoreactivity correlated with shorter survival in glioma pts
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