Neurology Medical News about long-standing retinal visual field defects;cortical grey matter density

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Changes in cortical grey matter density associated with long-standing retinal visual field defects
Brain, 05/28/09

Boucard CC et al. – Findings indicate that long-term cortical deprivation, due to retinal lesions acquired later in life, is associated with retinotopic-specific neuronal degeneration of visual cortex. This degeneration may interfere with therapeutic strategies such as future application of artificial retinal implants for lesion-induced visual impairment.

Methods

Magnetic resonance imaging to assess effects of prolonged sensory deprivation in human visual cortex
Evaluation of high-resolution anatomical magnetic resonance images
Subjects had foveal (age-related macular degeneration) and peripheral (glaucoma) retinal lesions
Comparison with findings for age-matched controls

Results