Neurology Medical News about Parkinsons disease:neuroanatomical substrate;visuospatial and visuoperceptual impairment

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Neuroanatomical substrate of visuospatial and visuoperceptual impairment in Parkinson's disease
Movement Disorders, 05/06/09

Pereira JB et al. – Findings suggest that visuospatial and visuoperceptual dysfunctions reflect structural gray matter (GM) changes in temporo-parietal cortical regions in Parkinson's disease (PD) pts.

Methods

Study of magnetic resonance imaging patterns of GM atrophy underlying visuospatial and visuoperceptual impairment in PD
Application of voxel-based morphometry to 36 nondemented PD pts
Correlation of whole brain GM density with performance on 3 visuospatial and visuoperceptual tests
Group comparisons between pts and 20 healthy controls
Correlations between visuospatial performance and GM density in superior parietal lobules and superior occipital gyrus of PD pts

Results

Poor performance on visuoperceptual tests significantly associated with GM decreases in fusiform, parahippocampus, and middle occipital gyrus
Group comparisons between controls and pts showed widespread GM cortical reductions in PD, involving posterior temporal and parietal regions

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