Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. 2008 Exclusive Survey—Earnings: Good news for primary care income 3. Medicare pay-for-reporting effort draws fire from frustrated doctors 4. Debunking Myths in the US Healthcare System 5. Doctors and the DEA Free full text
Top Ten Searches
parkinson's neuritis neuralgia myasthenia gravis lactic acidosis ataxia seizure tinnitus migraine hypotoniaYour Article Summary
See Latest ArticlesEffectiveness and safety of treatments for degenerative ataxias: A systematic review
Movement Disorders, 05/06/09
Trujillo-Martín MM et al. – Availability of quality studies to evaluate the safety and efficacy of treatments for most degenerative ataxias (DA) is scarce. No valid information on the actual value of physical rehabilitation and psychological support as treatments for DA is available. Further studies are needed with improved trial designs.
Methods- Study of effectiveness and safety of available treatment alternatives for DA
- Systematic review of studies to assess pharmacologic, rehabilitative, or psychological treatments in DA pts
- Assignment of score for methodologic quality of clinical trials in all 25 studies
- Main outcome measures: clinical status of neurological disorder, adverse events, and patient-based factors
- Most studies small sample sizes, wide age variations, and low scientific validity
- Information on physical rehabilitation in 1 study, but no information on psychological therapy
- Remaining 24 studies reported on effects of different pharmacologic treatments
- Few studies evaluated outcomes such as functional capacity and psychological functioning
- Some evidence supports that 5-hydroxytryptophan is more effective than placebo improving neurologic symptoms in pts with Friedreich ataxia (FA), olivopontocerebellar atrophy, or cerebellar atrophy
- Idebenone is more effective than placebo for halting and reversing hypertrophic cardiomyopathy associated with FA, but it seems unable to improve neurological semiology
Related Articles
Physiologic Alterations in Ataxia
Archives of Neurology, 10/19/09
Relevance Score: 67%
Intensive coordinative training improves motor performance in degenerative cerebellar disease
Neurology, 10/30/09
Relevance Score: 65%
Lumbar Segmental Mobility According to the Grade of the Disc, the Facet Joint, the Muscle, and the Ligament Pathology by Using Kinetic Magnetic Resonance Imaging
Spine, 11/02/09
Relevance Score: 45%
Dynamic Bulging of Intervertebral Discs in the Degenerative Lumbar Spine
Spine, 10/30/09
Relevance Score: 45%
Antioxidants and other pharmacological treatments for Friedreich ataxia
Cochrane Reviews, 10/09/09
Relevance Score: 45%
Today in Movement Disorders...keeping you current
Receive free subspecialty "5-minute updates" via email
Enhanced frontal function in Parkinson’s disease
Brain, 12/18/09
Hereditary spastic paraplegia caused by the PLP1 "rumpshaker mutation"
Journal of Neurology, Neurosurgery, and Psychiatry , 12/18/09
Impaired sensorimotor integration in focal hand dystonia patients in the absence of symptoms
Journal of Neurology, Neurosurgery, and Psychiatry , 12/18/09
Sponsor
Article Search
Sponsor
Sponsor