Neurology Medical News about dystnia;sensory functions;behavioral studies

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Sensory functions in dystonia: Insights from behavioral studies
Movement Disorders, 03/26/09

Tinazzi MD et al. – A number of different neurorehabilitative approaches explicitly manipulate somatosensory inputs to improve motor function, suggesting a causal link; however, whether they can trigger primary dystonia or are an epiphenomenon warrants further study.

Methods

Review of evidence for dysfunction of sensory processing in pts with dystonia
Assessment of whether this may lead to abnormalities in a crucial role of the basal ganglia that links sensory information to appropriate motor output

Results

Sensory function, particularly in the somatosensory domain, is compromised in pts with primary dystonia, both in adult onset focal dystonia and in genetically characterized DYT1 dystonia
Given that nonaffected DYT1 gene carriers may show similar abnormalities to clinically affected pts, sensory deficits could constitute a subclinical endophenotypic trait of disease that precedes overt clinical manifestations

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