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See Latest ArticlesNeuroimaging findings in isoniazid central nervous system toxicity, presumed intramyelinic edema
European Journal of Paediatric Neurology, 07/24/08
Hawkes M et al. - Author describe the clinical course and striking neuroimaging findings of a child with central nervous system toxicity due to isoniazid. Serum isoniazid level was in the toxic range, the result of a dispensing error as well as a possible pharmacogenetic factor. Author postulate that these imaging findings were the result of intramyelinic edema, previously described in experimental animal models of isoniazid toxicity.
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