Fulminant JC virus encephalopathy with productive infection of cortical pyramidal neurons Wuthrich C et al. - The polyomavirus JC (JCV) is the causative agent of progressive multifocal leukoencephalopathy and of JCV granule cell neuronopathy. A human immunodeficiency virus-negative patient who experienced development of multiple cortical lesions, aphasia, and progressive cognitive decline after chemotherapy for non-small-cell lung cancer is presented. [more...]