Quantitative assessment of brain iron by R2* relaxometry in patients with clinically isolated syndrome and relapsing-remitting multiple sclerosis
Khalil M et al. – Quantitative assessment by R2* relaxometry suggests increased iron deposition in the basal ganglia of multiple sclerosis (MS) pts, associated with disease duration and brain atrophy. This technique, with long-term follow-up may clarify whether regional iron accumulation contributes to MS morbidity or merely reflects an epiphenomenon. Methods- Study of regional brain iron deposition in pts with a clinically isolated syndrome (CIS) or relapsing–remitting MS (RRMS) and its associations with demographical, clinical, and conventional magnetic resonance imaging (MRI) parameters
- Assessment of 69 pts (32 CIS; 37 RRMS) with 3T MRI
- Analysis of regional R2* relaxation rates and correlations with age, disease duration, disability, T2 lesion load, and normalized brain volumes
Results- Basal ganglia R2* relaxation rates increased parallel with age; significantly higher in RRMS vs CIS
- On multivariate linear regression analysis, rate of putaminal iron deposition independently predicted by pt age, disease duration, and gray matter atrophy
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