Cognitive dysfunction in primary progressive multiple sclerosis: A neuropsychological and MRI study
Ukkonen M et al. – A study of cognitive dysfunction in multiple sclerosis (MS) focuses on cognitive performance in primary progressive MS (PPMS)and reports impairment in several cognitive domains. Methods- Study of the pattern of cognitive performance in PPMS
- Extensive battery of neuropsychological tests for 28 PPMS pts
- Comparison of results to those of 20 healthy controls and 28 pts with secondary progressive MS (SPMS)
- Correlation of results of neuropsychological tests in PPMS with magnetic resonance imaging findings
Results- Deficits in several cognitive domains for PPMS pts vs age-matched and education-matched controls
- Cognitive impairment similar for PPMS and SPMS pts
- Correlations for cognitive deficits in PPMS pts with diffuse brain lesion, T1- and T2-lesion loadl no correlations with atrophy
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