Intensity of pain and biochemical changes in blood plasma in spinal cord trauma
Yamamotova A et al. – After spinal cord injury, lower total cholesterol levels reflected more serious trauma intensity and HDL cholesterol predicted more intensive pain. Pain was less intensive for subjects responsible vs not responsible for their own injuries. Methods- Cross-sectional, observational and longitudinal study
- Analysis of relationship between pain intensity, plasma lipids and severity of spinal cord injuries in pts with paraplegia (11), tetraplegia (16) and polytrauma (15)
- Focus on hospitalization period immediately following injury
- Blood samples and assessment of pain intensity by visual analog scale immediately after pt transport to hospital, again 14 days after injury and before discharge from hospital
- Measurement of biochemical parameters: total protein, albumin, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, glycemia, and C-reactive protein
- Data analysis by injury type, state of unconsciousness immediately after injury, hemorrhage, measure of liability (self-inflicted injuries vs casualties), accident cause, and pre-injury cholesterol levels
Results- On day of injury, pain intensity correlated positively with HDL cholesterol
- On day of discharge from hospital, pain intensity correlated positively with blood glucose levels
- Diagnostic subgroups did not differ either in pain intensity or in pain dynamics during hospitalization
- Total cholesterol level lowest in pts with polytrauma
- In all pts, lowest total cholesterol level immediately after injury
- HDL cholesterol highest after injury
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