α-synuclein, alcohol use disorders, and Parkinson's disease: A case–control study
Brighina L et al. – Findings suggest that α-synuclein gene promoter (SNCA REP1) genotype and alcohol use disorders are independently associated with Parkinson disease (PD). Methods- Study to clarify association patterns between REP1 genotype, alcohol use disorders, and PD
- Cases recruited from Mayo Clinic Neurology Department; 893 case–control pairs
- Controls: unaffected sibling controls and unrelated controls
- Assessment of alcohol use via a structured phone interview
- Screen for alcohol use disorders by CAGE questionnaire
- REP1 genotyping with ABI 3730XL platform
Results- Increasing risk of PD with increasing SNCA REP1 allele length
- Decreasing risk of PD with increasing CAGE score
- Association of REP1 score with PD remained significant after adjusting for CAGE score
- Association of CAGE score with PD remained significant after adjusting for REP1 score
- No pairwise interactions
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