Neuroprotective effects of estrogens following ischemic stroke
Suzukia S et al. – A review of the current understanding of neuroprotective actions of estrogens against ischemic stroke discusses the implications for improving quality of life in aging populations. Methods- Review of neuroprotective effects of estrogens following ischemic stroke
- Study of whether and how 17beta-estradiol (E2) protects the brain against neurodegeneration associated with cerebrovascular stroke
Results- Low, physiologic concentrations of E2 dramatically protect brain against stroke injury
- Multiple signaling pathways and key genes mediate protective action of E2
- E2 concentrations strikingly similar to low-basal circulating levels in cycling mice
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