Narcolepsy: Action of Two gamma-Aminobutyric Acid Type B Agonists, Baclofen and Sodium Oxybate
Huang Y-S et al. - The dose of baclofen demonstrating an effect on nocturnal sleep without negative side effects was determined and maintained. Both drugs increased total sleep time and delta waves during sleep, but only sodium oxybate had an effect on daytime sleepiness and cataplexy at 3 months. Improvement of total nocturnal sleep time had no beneficial effect on daytime sleepiness. The mechanism by which sodium oxybate improves cataplexy and sleepiness is inferred to be due to properties beyond direct GABAB agonist action. [more...]
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