Neuroanatomical substrate of visuospatial and visuoperceptual impairment in Parkinson's disease
Pereira JB et al. – Findings suggest that visuospatial and visuoperceptual dysfunctions reflect structural gray matter (GM) changes in temporo-parietal cortical regions in Parkinson's disease (PD) pts. Methods- Study of magnetic resonance imaging patterns of GM atrophy underlying visuospatial and visuoperceptual impairment in PD
- Application of voxel-based morphometry to 36 nondemented PD pts
- Correlation of whole brain GM density with performance on 3 visuospatial and visuoperceptual tests
- Group comparisons between pts and 20 healthy controls
- Correlations between visuospatial performance and GM density in superior parietal lobules and superior occipital gyrus of PD pts
Results- Poor performance on visuoperceptual tests significantly associated with GM decreases in fusiform, parahippocampus, and middle occipital gyrus
- Group comparisons between controls and pts showed widespread GM cortical reductions in PD, involving posterior temporal and parietal regions
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