Current and future immunotherapy in myasthenia gravis
Future Neurology, 11/20/2009
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Katzberg HD et al. – This paper reviews both the current accepted treatments for myasthenia gravis as well as promising targeted therapies in development.
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Coexistent autoimmune autonomic ganglionopathy and myasthenia gravis associated with non-small-cell lung cancer
Muscle & Nerve, 11/10/2009
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Peltier AC et al. – Autoimmune autonomic ganglionopathy and myasthenia gravis can coexist and suggest that the latter should be excluded in patients with autoimmune autonomic ... improvement with non–supine rest.
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Autoimmune Polyglandular Syndrome Type 2 With Myasthenia Gravis Crisis
The Neurologist, 11/20/2009
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Konno S et al. – The authors describe a rare case of autoimmune polyglandular syndrome type 2 initially presenting as Addison disease and autoimmune thyroid disease, with subsequent development of autoimmune hepatitis and myasthenia gravis (MG) crisis in ... performed. Conventional treatment for MG was effective and safe in this case, in which there was positivity for human leukocyte antigen A23, B52, B62, DR11, and DR15.
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Adult celiac disease with acetylcholine receptor antibody positive myasthenia gravis
World Journal of Gastroenterology, 10/19/2009
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Freeman H et al. – Endoscopic studies subsequently showed duodenal mucosal scalloping and biopsies confirmed the histopathological changes of celiac disease. Celiac disease and myasthenia gravis may occur together more often than is currently ... motor weakness in celiac disease may be a clue to occult myasthenia gravis, even in the absence of intestinal symptoms.
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Co-existence of Euthyroid Graves Ophthalmopathy and Isolated Ocular Myasthenia in a Patient with Vitiligo: A Challenging Diagnosis of Auto-immune Polyglandular Syndrome-3C
Neuro-Ophthalmology, 10/15/2009
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Pepene CE et al. – The authors report a case of euthyroid Graves ophthalmopathy associated with isolated ocular myasthenia gravis appearing in a patient with ... compatible with an autoimmune polyglandular syndrome–3C phenotype. The coexistence of these two entities, in the absence of either overt thyroid dysfunction or generalized features of myasthenia gravis may cause diagnostic confusion.
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Expanded TCR V-beta subsets of CD8+ T-cells in late-onset myasthenia gravis: Novel parallels with thymoma patients
Journal of Neuroimmunology, 10/05/2009
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Tackenberg B et al. – The CD8+ TCRV–beta expansions were stable over 5years, but RTE markers declined.
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Serum Protein Profiles in Myasthenia Gravis
Annals of Thoracic Surgery, 10/13/2009
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Cheng C et al. – SELDI TOFMS is a useful tool for the detection and identification of potential serum biomarkers that can diagnose MG with high sensitivity and specificity.
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Factors associated with response to calcineurin inhibitors in myasthenia gravis
Muscle & Nerve, 10/13/2009
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Nagane Y et al. – Multivariate logistic regression analysis revealed time since onset of disease and presence of thymoma as clinical factors that predict response to CNIs. As for MG–related autoantibody ... channel, Kv1.4, was associated with response and showed a correlation with the presence of thymoma. In MG, the early stages of disease and thymoma–associated MG are responsive to treatment with CNIs
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Muscle strength and fatigue in patients with generalized myasthenia gravis
Muscle & Nerve, 10/19/2009
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Symonette CJ et al. – Patients with MG reported greater fatigue than controls. Muscle strength was lowest in the D–MG group, followed by the ND–MG group and controls. Normalized shoulder abduction fatigue ... and ND–MG groups or controls. The RNS decrement appears to relate best to disease severity and muscle weakness but not to objective measures of fatigue in this population.
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Determinants of cognitive impairment in elderly myasthenia gravis patients
Muscle & Nerve, 10/08/2009
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Marra C et al. – This study does not support the hypothesis of CNS cholinergic involvement in MG. The impairments of attention, memory, and control tasks in MG are related to general visual motor slowness and to the ... neuropathy/myopathy
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